Expanded Programme on Immunisation
The National Immunisation Programme (NIP) is a high priority programme (P1) of Government of Nepal. Immunization is considered as one of the most cost-effective health interventions. Effective implementation of the Immunization programme is considered to contribute directly to the reduction of infant, child morbidity and mortality and ultimately will contribute to achieve millennium development goal.
Vaccine-preventable diseases (VPDs) are routinely reported through the HMIS and outbreak response complemented by active integrated surveillance of AFP with the support of Immunization Preventable Diseases/WHO. This includes surveillance of Measles, NT and Japanese Encephalitis.
The National immunization programme covers all the 75 districts of the country. It is striving hard to have uniform high coverage in all the districts and sustain it (i.e. at least 90 percent for BCG, OPV3, DPT-Hepatitis B3, and measles vaccine in children under one year of age and 80 percent for TT2+ in pregnant women). There are still pockets of low coverage VDCs and districts. Due to weak immunization structure coverage is low in most of the municipalities.
The overall goal of the EPI programme is to reduce child morbidity, mortality and disability associated with vaccine-preventable diseases.
1.2.1 Achieve and sustain immunization coverage of >90 percent in National level with >80 percent in all districts and below for all antigens.
1.2.2 Maintain a polio-free status.
1.2.3 Eliminate maternal and neonatal tetanus by 2005 and sustain the status.
1.2.4 Reduce measles mortality by 50 percent from 2003 levels and sustain the achievement.
1.2.5 Integrate the surveillance of additional VPDs into the existing surveillance system.
1.2.6 Strengthen and sustain the vaccine and logistics management system.
1.2.7 Introduce new and under used vaccines into the National Immunization Program on the basis of disease burden.
1.3.1 All infants (under one year – 12 months) for BCG, DPT-HepB, OPV, and Measles vaccines
1.3.2 All pregnant women for TT2+ vaccine
1.3.3 All 1, 2 and 3 grade students for School Immunization Programme.
The table below provides a schedule for immunizations at different ages.
|Type of Vaccine||Number of Doses||Recommended Age|
|BCG||1||At birth or on first contact|
|OPV||3||6, 10, and 14 weeks of age|
|DPT – Hep B||3||6, 10, and 14 weeks of age|
|Measles||1||9 months of age|
NIP under Child Health Division has a lead role in all immunization-related activities at the National level including coordinated actions with other Divisions of the DoHS and all other partners. The Regional Health Directorate (RHD) acts as a facilitator between the Central and the District levels. It is the responsibility of the D(P)HO to ensure that a successful immunization program is implemented at the district level. Primary Health Centers (PHCs), Health Posts (HPs), and Sub-Health Posts (SHPs) implement immunization programs in their Village Development Committees (VDCs)
Delivery of Services
NIP delivers the Immunization services through Routine and Supplemental Immunization Programs
- Routine Immunization
The National Immunization Program delivers routine immunization through fixed health facilities, outreach programs, and mobile teams.
- Fixed facilities: Immunization services are provided at hospitals, primary healthcare centers, health posts and sub health posts. Some health facilities equipped with refrigerators provide immunizations daily and some provide weekly.
- Outreach services: Provide access to the people who have difficulty in reaching health facilities due to long distance to travel, three to five immunization sessions a month are conducted at several locations in each VDC. The frequency of outreach services is based on village setting, population density, and seasonal variations. These sessions account for more than 90 percent of immunization coverage.
- Mobile teams: Geographical conditions such as lack of roads and bridges hamper immunization in remote areas. Due to vacant or frequent absenteeism of health worker in remote areas, there is poor access of target population to routine immunization. These areas are identified and appropriate strategy are developed during micro-planning. To address these issues, at least four visits to identified hard-to-reach areas by vaccinators are mandatory through mobile teams to immunize targeted population.
Though the immunization service is mainly delivered through government health network, there is increasing trend of immunization service delivery through private sector. This is due to the realization of Public Private Partnership in Health Sector Reform Strategies of government. In private sector, immunization services are delivered through private clinics, hospitals, nursing homes as well as NGOs. Government supplies all vaccines and immunization related logistics to these private institutions free of cost. All vaccine under National Immunization Program are given free of cost or there is no cost sharing / recovery.
The indicators used for National Immunization program monitoring are as follows:
|Main Indicators||Numerator and Denominator|
|1 Immunisation coverage||Number of children under one year of age immunised with specific dose of antigen|
|Total estimated number of children under one year of age|
|2 Immunisation coverage for TT2+ vaccine||Number of pregnant women immunised with TT2+|
|Total estimated number of pregnant women|
|3 DPT-Hep-B drop-out rates|
(DPT-HepB1 vs. DPT-HepB3)
|Number of children received DPT-HepB1 – Number of children received DPT-HepB3|
|Number of children received DPT-HepB1|
|5 Measles drop-out rates (BCG vs. Measles vaccine)||Number of children received BCG – Number of children received Measles vaccine|
|Number of children received BCG|
|6 Vaccine Wastage Rate||Number of vaccine doses received – Number of vaccine doses used|
|Number of vaccine doses received|
|7 Immunization Session||Number of Immunization Session conducted in a year|
|Number of total immunization session planed in a year|
|8 AFP Surveillance||At least 2 AFP cases in 100,000 population per year|
|9. NT Surveillance||No or less than one NT case in 1,000 live birth per year per district|
For the purpose of monitoring of the EPI activities wastage rate and morbidity due to vaccine preventable diseases is also taken into consideration.
The strategies to achieve the above objectives are:
1.5.1 Provide immunisation services through all health facility, EPI outreach sessions; Mobile Clinics
1.5.2 Conduct supplemental immunisation activities for:
– Polio eradication
– Measles and JE control
1.5.3 Expansion of School Immunization Program to sustain MNT elimination
1.5.4 Strengthen monitoring system of Immunization Program:
- VDCs wise data analysis, categorization, and prioritisation for action at districts level
- Use of immunization monitoring chart
- Review of Immunization Program at different level and feedback
1.5.5 Conduct districts level Micro-planning
1.5.6 Strengthen and expand integrated surveillance of VPDs built on AFP Surveillance (AFP, Measles, Neonatal Tetanus and Japanese encephalitis) and initiation of study of disease burden of other vaccine preventable diseases like Hib and Rubella.
1.5.7 Control outbreak of VPDs through appropriate interventions;
1.5.8 Increase and promote public awareness and demand through social mobilisation for immunisation services and IEC/BCC interventions.
1.5.9 Strengthening of cold chain capacity in all 75 districts and ensure their functioning
1.5.10 Training to Health Workers (Mid Level Manager and Cold Chain Assistant)
1.5.11 Strengthening and expansion of AEFI surveillance
1.5.12 Strengthen supportive supervision
2 ANALYSIS OF ACHIEVEMENTS BY MAJOR ACTIVITIES
2.1 Major Activities Carried Out in FY 2062/63 (2005/2006)
The following were the major activities carried out during FY 2062/63
2.1.1 Conduction of immunisation services through three to five outreach immunisation sessions per Village Development Committee (VDC) per month;
2.1.2 Continuation of immunisation services through health facility based clinics located at the hospitals, PHCCs, HPs and SHPs;
2.1.3 Provided training on immunization for various levels of health workers (Mid Level Manager and Cold Chain Assistant training).
2.1.4 Expanded and continued integrated VPDs Surveillance (AFP, Measles and NT) including JE Surveillance.
2.1.5 Initiated Hib diseases burden study
2.1.6 Conducted Responsive Mopping-up activity in 5 Terai districts of Nepal
2.1.7 Conducted Sub-National Immunization Days (SNID) for Polio Eradication Initiatives in 21 high-risk districts of Nepal (bordering with India).
2.1.8 Established Polio static booths (131 booths) on bordering districts with Bihar and UP of India in response to the supplementary immunization activities.
2.1.9 Completed districts micro-planning in 20 districts
2.1.10 Conducted performance review of immunization program at different level
2.1.11 Developed multi year plan of action (2007-2011)
2.1.12 Implemented of School Immunization Activities in 8 districts
2.1.13 Developed and print Immunization Atlas of Nepal.
2.1.14 Revised, Printed and Distributed Immunization Monitoring Chart
2.1.15 Completed JE Vaccination Campaign in 6 hyper endemic districts
2.1.16 Districts NIP performance was verified through Data Quality Self Assessment in 10 districts
2.2 TARGET vs. ACHIEVEMENT, FY 2062/63 (2005/2006)
During FY 2062/63, the EPI target was to cover 90 percent of under-one-year children. However, the achievement shows that the BCG coverage was 96.1 percent, DPT3 93.0 percent, OPV3 91.9 percent and Measles 87.5 percent. Overall coverage for all the vaccines increased in this FY compared to previous fiscal year 2061/62.
|SN||Activities||Unit||Targets||Achievement||Target vs. Achievement (percent)|
|5||Hepatitis B I vaccination||Infants||742,164||655,774||88.4|
|6||Hepatitis B II vaccination||Infants||742,164||653,122||88.0|
|7||Hepatitis B III vaccination||Infants||742,164||661,584||89.1|
|12||TT2 vaccination||Pregnant women||941,890||482,841||51.3|
|13||Polio Responsive Mopping-up activity €“ I Round||Under 5 yrs Children||475,617||471,460||99.1|
|14||Polio Responsive Mopping-up activity €“ II Round||Under 5 yrs Children||475,617||476,586||100.2|
|15||Polio Responsive Mopping-up activity €“ III Round||Under 5 yrs Children||475,617||482,922||101.5|
|16||Polio SNID in 15 Districts €“ I Round||Under 5 yrs Children||1,796,760||1,756,422||97.8|
|17||Polio SNID in 15 Districts €“ II Round||Under 5 yrs Children||1,796,760||1,770,453||98.5|
|18||Polio SNID in 6 Districts €“ I Round||Under 5 yrs Children||597,683||554,452||92.8|
|19||Polio SNID in 6 Districts €“ II Round||Under 5 yrs Children||597,683||546,951||91.5|
Source: HMIS/MD and EPI/CHD, DoHS
Analysis of the reports from all 75 districts of the country for FY 2062/63 shows that overall coverage level for BCG vaccination is 96.1 percent, measles vaccination is 87.5 percent, DPT3 93.0 percent, OPV3 91.9 percent and Tetanus Toxoid (TT2) is 51.3 percent. However, coverage for all antigens are not uniform among the districts and within the VDCs of the districts, some of the districts achieving more than 100 percent coverage, and others are far behind.2.3 ANALYSIS OF SERVICE STATISTICS
The table 2a.1 and figure 2a.1 present the annual immunisation coverage of BCG, DPT, OPV, and measles vaccine in Nepal from FY 2060/61 to 2062/63. The figures are expressed in percentage of the targeted population for each fiscal year. It has been observed that the coverage of all antigens increased in FY 2062/63 compared to FY 2061/62.
Table 2a.1 Annual Immunisation Coverage in Nepal, FY 2060/61 to 2062/63
Source: HMIS/MD, DoHS
Based on DPT3 coverage and DPT1 vs. DPT3 dropout rates, categorisations of the districts as per their performance are shown in the District Categorized table. Districts under category 4, 3 and 2 respectively are the most concerned for NIP to address their access and utilization problem. Activities carried out to address the problems were to revise immunization session through micro-planning, to trace missed children for successive doses, to mobilize FCHVs and involve community leaders. Districts under category 1 were continuously monitored for sustaining their achievements.
Table 2a.2 Immunisation Coverage (Percent), by Region, FY 2060/61 to 2062/63
|BCG (<1 year)|
|DPT3 (<1 year)|
|Polio3 (<1 year)|
|Measles (<1 year)|
Source: HMIS/MD, DoHS
Figure 2a.2 shows the trend in coverage of Measles vaccine for last 3 FYs. The coverage has increased in all the regions in FY 2062/63 with highest coverage (91.6 percent) being in MWDR and lowest (80.0 percent) in WDR. The national coverage of Measles vaccination is increased by 8.2 percent in FY 2062/63 as compared to FY 2061/62.
Figure 2a.4 shows the DPT1 vs. DPT3 dropout rate by region. The drop out rate stands between -2.1 to 1.6 percent in FY 2062/63 with the highest rate in CDR (1.6 percent) and lowest in EDR (-2.1 percent). The national figure for the DPT1 vs DPT3 dropout rate stands at 0.0 percent in the FY 2062/63, which is a significant achievement of the NIP program of Nepal.As shown in figure 2a.3, the national coverage for TT2 vaccination in pregnant women was 44.9 percent in 2061/62. However, in FY 2062/63 the TT2 coverage increased by 6.4 percent points at the National level (51.3 percent). The percentage of pregnant women immunised with TT2 vaccine increased in all the region in the FY 2062/63. The coverage was highest in EDR (56.4 percent) and lowest in FWDR (48.1 percent).
The Vaccine Wastage Rate (figure 2a.6) of all antigens has been observed as follows in FY 2062/63: BCG 74.8 percent, DPT 21.3 percent, Polio 24.7 percent and Measles 59.4 percent. The wastage rate of vaccines, especially BCG & Measles compared to normally accepted rate is still a challenge.Figure 2a.5 shows the BCG vs. Measles dropout rate. It has decrease from 14.2 percent in FY 2061/62 to 8.9 percent in FY 2062/63 at National level. The highest dropout rate was observed in the CDR with 12.0 percent, and lowest in MWDR 5.5 percent. There is a trend of improvement in the dropout rate in general.
According to figure 2a.7, the lowest number of BCG vaccination was observed during the month of Chaitra. The month-wise BCG vaccination trend is seen to be considerably better in FY 2062/63 compared to FY 2060/61 and FY 2061/62.
2.4.1 National Immunisation Days (NIDs) for Polio Eradication2.4 SUPPLEMENTARY IMMunization activities
To eradicate poliomyelitis, EPI continued to implement a programme of “Intensified National Immunization Days” (INID) in two rounds from 2053/54 to FY 2060/61. In the first year NIDs were conducted successfully in two rounds in 2053/54 (on 6 December 1996 and 17 January 1997). Consecutively every year two rounds of NIDs were being conducted. Besides, Sub-National Immunization Days, Pre-emptive Mopping-up and Responsive Mopping-up Activities in high-risk districts mainly districts bordering with India and Kathmandu Valley were also conducted. Intensified National Immunisation Days was not implemented during FY 2061/62 and 2062/63.
Nepal has not detected any poliomyelitis case caused by wild poliovirus for the last four years (year 2001 to 2004) most probably because of high NID coverage of around 100 percent (see above figures). But in the FY 2061/62 four polio cases were detected in Sarlahi and Rautahat district which were imported from India one polio case was detected in 2062/2063 in Dailekh district of Nepal. Acute Flaccid Paralysis (AFP) Surveillance, is becoming a major activity in the eradication of polio from the country. Nepal has expanded active surveillance of polio to neonatal tetanus and measles from FY 2060/61 through the AFP-surveillance site and in FY 2061/62 JE surveillance was also integrated with VPDs surveillance.
2.4.2 Measles Campaign to Control Measles in Nepal
It was estimated that every year some 150,000 children are infected with measles and some 2,700 die due to its consequences. To prevent this huge amount of deaths and measles cases, Nepal conducted a successful campaign throughout the Kingdom aiming to reduce 50 percent of child mortality due to measles complications. The success of this campaign created history in the field of public health by immunizing about 10 million children. The Measles Campaign was conducted in a phase wise manner and the coverage of measles through the campaign was very satisfactory in the year 2004 and 2005. Good social mobilisation, active local participation, and assistance from various partner agencies contributed to the success of NIDs, Measles campaign and MNTE activities. The result of this campaign are very encouraging in terms of reduction of measles outbreaks and children affected. However, to sustain this status is a challenge and to overcome this situation, initiatives like increasing coverage above and around 80 percent be reached through routine immunization strategies. Hence, RED strategies have been incorporated in multi-year plan of action 2007-2011, which clearly states the activity to strengthen routine immunization.
Table Showing Effect of Measles Campaign:
|Measles outbreaks (Lab confirmed)|
Note: Data as of 05 December 2005 (through active surveillance) Source: WHO/IPD
2.5 INTRODUCTION OF HEPATITIS B VACCINE
Introduction of Hepatitis B in the routine immunization program was done in all 75 districts by FY 2061/62. From the FY 2062/63 DPT-HepB (Combo Vaccine) vaccine has replaced DPT vaccine in all Districts of Nepal.
3 PROBLEMS/CONSTRAINTS AND ACTIONS TO BE TAKEN
|HMIS, CHD, DHO and local health facility|
|Some of newly supplied freezes and defreeze to districts and sub centre are not functioning||LMD/CHD|
|Problem for regular cold chain maintenance|
No trained manpower for repairing the non functioning cold chain equipment at regional/ District level
No contingency plan for cold chain
|Delayed procurement of vaccine|
Irregular and short supply vaccine
|Some of the VHWs are old and disable, cannot conduct the EPI session.||CHD/ DHO and Health facility|
|Coverage to hard to reach population||IDENTIFY THE UNDER SERVED or missed children||Health facility, DHO/PHO/ CHD|
|There is no clear guideline to send HA, SAHW, Staff Nurse for EPI out reach clinics||CHD/DoHS|
|Regular monitoring of immunization program using developed monitoring tools and quality information collection on immunization||Health facility incharge /District EPI Supervisors /DHO/DPHO|
|Injection safety in immunization|
And AEFI surveillance
|DHOs/ RHDs/ CHD|
|Social mobilization, community participation and local ownership||DHO and Local Health facility|
|Quality of review at different level and micro planning and data quality self assessment||CHD/RHD, DHO and HF management committee.|
|Vaccine management at different level is poor leading to irregularity in session conduction and increase in vaccine wastage||DHO/LMD/CHD|
|BCC activities to increase demand of immunization||NHEICC/ CHD|
|Weak supportive supervision||All levels|
|Training manuals needs to be revised as per present context||CHD|
4 TARGETS FOR FY 2063/64 (2006/2007)
|1||Routine Immunisation activities aiming for higher coverage||Children <1 year||747,567|
|2||TT2+ Immunisation for all pregnant women||Pregnant women||961,241|
Source: EPI/CHD, DoHS
Note: For detailed, district-specific data and analysis on this programme/project, please refer to the relevant annexes in this document.